Anxiety-like Behavior in Female Sprague Dawley Rats Associated with Cecal Clostridiales
نویسندگان
چکیده
The relationship between the microbiota profile and exposure to stress is not well understood. Therefore, we used a rat model of unpredictable chronic mild (UCMS) investigate this relationship. Depressive-like behaviors were measured in Female Sprague Dawley rats using sucrose preference test Porsolt swim test. Anxiety-like with light–dark box Fecal corticosterone, cecal (composition organic acids), plasma gut permeability (lipopolysaccharide-binding protein, LBP) inflammation (12 cytokines) markers measured. Atypical observed female following UCMS, but no depressive-like observed. Circulating concentrations cytokines granulocyte-macrophage colony-stimulating factor cytokine-induced neutrophil chemoattractant 1 higher UCMS-exposed rats; LBP acid levels remained unchanged. Our results reflect resilient adaptive phenotype for SD rats. relative abundance taxa from Clostridiales order Desulfovibrionaceae family did, however, correlate both positively negatively anxiety-like cytokine concentrations, regardless UCMS exposure, supporting brain-to-gut influence anxiety that may involve inflammatory pathways.
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ژورنال
عنوان ژورنال: Microorganisms
سال: 2023
ISSN: ['2076-2607']
DOI: https://doi.org/10.3390/microorganisms11071773